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W507- Health Effect of Hazardous Substances



The course introduces students to the health hazards of substances that are used at work. It describes where hazardous substances are commonly used in industry and what their harmful effect can be. It also explains the underpinning principles of physiology, toxicology and epidemiology.


Ø  5-days course [minimum 45 hours including practical/demonstration sessions, lectures, tutorials, guided reading, overnight questions and examination].

Ø  There will be a 40 short answer questions “open book” examination with an allowed time of 120 minutes.


On completing this course successfully, the student will be able to:

·       Provide definition of commonly used toxicological terms

·       Describe the main routes by which hazardous substance can enter the body, and the factor which influence their absorption, distribution, storage and elimination

·       Describe the main source of information on hazardous substances and processes

·       Recognize hazardous substances in the workplace

·       Describe the main features of the principal  target organs affected by hazardous substance at work, and the factors which influence the degree of harm

·       Describe the main feature of exposure for hazardous substances commonly encountered in the workplace

·       Describe the health effect of some common hazardous substances

·       Undertake basic interpretation of the results from epidemiological studies


 1. Introduction of Toxicology

1.1 Introduction and historical perspective

1.2 Some basic toxicological term and concepts

2.Type of Health Effects

             2.1 Asphyxiation

             2.2 Irritation

             2.3 Narcosis

             2.4 Systemic toxicity

             2.5 Genotoxicity and carcinogenicity

             2.6 Sensitisation (Allergic reaction)

             2.7 Reproductive effects

3. Basic Human Biology and Target Organs

             3.1 Respiratory system

             3.2 The skin

             3.3 Nervous system

             3.4 Circulatory system

             3.5 Liver

             3.6 Kidney

             3.7 Reproductive system

4. Basic Toxicokinetics

             4.1 Absorption

             4.2 Distribution and storage

             4.3 Metabolism

             4.4 Excretion

5. Dose Response Curves and Toxicity Testing

             5.1 Introduction to dose-response curves

             5.2 Toxicity testing

6. Epidemiology

             6.1 Introduction

6.2 Reasons for undertaking epidemiological studies

6.3 Types of epidemiological studies

7. Overview of Health Effects

             7.1 Introduction

             7.2 Gases

             7.3 Organic solvents and vapours

             7.4 Other selected organic liquid

             7.5 Metals and metal compounds

             7.6 Dusts and particulate materials

             7.7 Mineral fibres

8.Common Industrial Processes

             8.1 Introduction

             8.2 Material handling

             8.3 Working with metals

8.4 Surface coating and treatment of metals

8.5 Soldering and brazing

             8.6 Degreasing

             8.7 Painting

9. Specific Industry Profiles

             9.1 Introduction

9.2 Smelting and refining of iron and steel

9.3 Foundries

9.4 Mining and quarrying

9.5 Oil and Petroleum

9.6 Pharmaceutical industry

10. Regulatory Consideration

             10.1 Risk and safety phrases

             10.2 sources of information

11. Biological hazards

             11.1 Introduction to biological hazards

             11.2 Legionella and humidifier fever

             11.3 Blood borne disease

             11.4 Zoonoses

Training info

Status: This event is approved by OHTA for the international qualifications scheme
Approved by OHTA
Category: Hazardous Substances
Level: Intermediate
Training provider: Sustainable EHS LLP


Location Gandhinagar / Vadodara
Starts 11 Nov 2019 09:00
Ends 15 Nov 2019 18:00
Course leader Utpal Bhavsar CIH, CSP & Lavish Lokhande CIH, CSP, CHMM, CMIOSH
Places 10
Website visit site
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